Hemorrhagic septicemia (HS) is a highly infectious disease among cattle and buffaloes characterized by an acute fatal septicemia condition with high morbidity and mortality. An outbreak of Hemorrhagic septicemia (HS) was occurred in Pottuvil range at Western part of Komari Junction in a buffalo herd. Immediate action has been taken under leadership of Deputy Director Ampara and veterinary surgeon Pottuvil and started vaccination programme in that area to make herd immunity as preventive measure. The Disease outbreak was successfully controlled